Lee County was created in 1887 from Monroe County. It was named for Robert E. Lee, Confederate general in the American Civil War.

Incorporated in 1886, Fort Myers is the center of a popular tourist area in Southwest Florida and the seat of Lee County. It is located about 120 miles (190 km) south of Tampa at the meeting point of the Gulf of Mexico and the Caloosahatchee River. Fort Myers was the frequent winter home of Thomas Edison, as well as Henry Ford. Lee County has been the host to several Major League Baseball teams for Spring Training, over the past several decades. Currently, it is the spring home of the Boston Red Sox, as well as the Minnesota Twins.

Fort Myers, built in 1850 as a military fort to fend off Seminole Indians that were massacring the area’s few settlers, was named after Col. Abraham C. Myers, who was stationed in Florida for seven years and was the son-in-law of the fort’s establisher and commander. In 1858, after years of elusive battle, chief Billy Bowlegs and his warriors were persuaded to surrender and move west, and the fort was abandoned. Billy’s Creek, which flows into the Caloosahatchee River, was named after a temporary camp where Billy Bowlegs and his men awaited ships to take them west.

In 1863, the fort was reoccupied by Federal troops during the Civil War. In 1865 the fort was attacked unsuccessfully by a small group of Confederates. After the war, the fort was again deserted.

The first settlers arrived in 1866, but it was not until 1882 when the city experienced a significant influx of settlers. By 1885, when Fort Myers was incorporated, it was the second largest city only to Tampa on Florida’s west coast south of Cedar Key, even larger than Clearwater and Sarasota, also growing cities at the time.

Fort Myers first became a nationally known winter resort with the building of The Royal Palm Hotel in 1898. But what really sparked the city’s growth was the construction of the Tamiami Trail Bridge built across the Caloosahatchee River in 1924. After the bridge’s construction, the city experienced its first real estate boom and many subdivisions sprouted around the city.

In 1923, Collier and Hendry Counties were created by splitting these areas from Lee County. As recently as 2004, discussion had taken place surrounding the possibility of the city of Cape Coral becoming its own county, citing in particular a perceived lack of infrastructure support from the Lee County government. However a new county has not as of yet been created.

On August 13, 2004, the county was hit hard by Hurricane Charley, a Category 4 storm, particularly on the northwestern islands of Captiva, Gasparilla and North Captiva.

Lee County is a county located in the U.S. state of Florida. The county makes up the entirety of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area, and is the most populous county in Southwest Florida.According to the U.S. Census Bureau, as of 2000, the population of Lee County was 440,888. The population estimate for 2008 was 623,725
Its county seat is Fort Myers and its largest city is Cape Coral.