Fort Myers is the county seat and commercial center of Lee County, Florida, United States. Its population was 48,208 in the 2000 census. According to 2008 estimates, the population is 68,689.

The city is one of two major cities that make up the Cape Coral-Fort MyersMetropolitan Statistical Area, the other being Cape Coral. As of 2008, the population estimate for the metropolitan area was 623,725.

Established in 1886, Fort Myers is the historical and governmental hub of Lee County. It is the gateway to the Southwest Florida region, which is a major tourist destination in Florida. The winter homes of Thomas Edison (Seminole Lodge) and Henry Ford (The Mangoes), which are both primary tourist attractions in the region, are located on McGregor Boulevard in Fort Myers.

On August 13, 2004, Fort Myers was hit hard by Hurricane Charley, a Category 4hurricane that made landfall north of the area. In 2005, Hurricane Wilma struck south of Naples, but caused extensive damage nonetheless in Fort Myers and its southern suburbs.

Southwest Florida International Airport (RSW) is located southeast of the city in South Fort Myers, near Gateway and Lehigh Acres.